Liver Tumors

Principal Investigators

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Prof. Matthias Matter

Leitender Arzt und Fachbereichsleiter Molekularpathologie

Pathologie

Tel. +41 61 328 64 71

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Group Members

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Dr. Simon Häfliger

Assistenzarzt

Pathologie

Tel. +41 61 32 87867

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Our Science

In our research, we focus on the interplay between the immune system and liver tumors. In particular, we’re interested to find out how chronic inflammation in the liver promotes liver cancer and how different types of inflammatory microenvironments influence the biology of liver cancer. In addition, we’re interested in oncogenes promoting liver tumors and what role they have in therapy responses. We’re working with human samples from liver cancer patients suffering also from chronic viral hepatitis or NASH/ASH.

 

In addition, we perform research in the field of molecular pathology and research on COVID-19, with a focus on the interplay between the immune response against SARS-Cov-2 and the effect on human tissue.  

  • Alborelli I*, Bratic I*, Chijioke O, Savic S, Bubendorf L, Leuenberger LP, Tolnay M, Leonards K, Quagliata L, Jermann P*, Matter MS*. Robust assessment of tumor mutational burden in cytological specimens from lung cancer patients. Lung Cancer. 2020 in press.
  • Haefliger S, Marston K, Juskevicius D, Meyer-Schaller N, Forster A, Nicolet S, Komminoth P, Stauffer E, Cathomas G, Hoeller S, Tornillo L, Dirnhofer S, Terracciano LM, Bihl M, Matter MS. Molecular Profile of Gastrointestinal Stromal Tumors in Sixty-Eight Patients from a Single Swiss Institution. Pathobiology. 2020 Feb 20:1-8.
  • O'Rourke CJ, Matter MS, Nepal C, Caetano-Oliveira R, Ton PT, Factor VM, Andersen JB. Identification of a Pan-Gamma-Secretase Inhibitor Response Signature for Notch-Driven Cholangiocarcinoma. Hepatology. 2020 Jan;71(1):196-213.
  • Faure-Dupuy S, Delphin M, Aillot L, Dimier L, Lebossé F, Fresquet J, Parent R, Matter MS, Rivoire M, Bendriss-Vermare N, Salvetti A, Heide D, Flores L, Klumpp K, Lam A, Zoulim F, Heikenwälder M, Durantel D, Lucifora J. Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection. J Hepatol. 2019 Dec;71(6):1086-1098.
  • Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J. , Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O´Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med. 2019 Apr;25(4):641-655.
  • Nuciforo S, Fofana I, Matter MS, Blumer T, Calabrese D, Boldanova T, Piscuoglio S, Wieland S, Ringnalda F, Schwank G, Terracciano LM, Ng CKY, Heim MH. Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies. Cell Rep. 2018 Jul 31;24(5):1363-1376.
  • Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN. The protein histidine phosphatase LHPP is a tumour suppressor. Nature. 2018 Mar 29;555(7698):678-682.
  • Quintavalle C, Hindupur S, Quagliata L, Pallante P, Nigro C, Condorelli G, Andersen JB, Tagscherer KE, Roth W, Beguinot F, Heim MH, Ng C, Piscuoglio S and Matter MS. Phosphoprotein Enriched in Diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib. Cell Death and Disease. 2017 Oct 26;8(10):e3138.
  • Quintavalle C, Burmeister K, Piscuoglio S, Quagliata L, Karamitopoulou E, Sepe R, Fusco A, Terracciano LM, Andersen JB, Pallante P, Matter MS. High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy. Mol Carcinog. 2017 Sep;56(9):2146-2157.
  • Rey S, Quintavalle C, Burmeister K, Calabrese D, Schlageter M, Quagliata L, Cathomas G, Diebold J, Molinolo A, Heim M, Terracciano LM, Matter MS. Liver damage and senescence increases in patients developing hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 Aug;32(8):1480-1486.
  • Matter MS, Marquardt JU, Quintavalle C, Andersen JB, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata C, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwälder M, Factor VM, Thorgeirsson SS. Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype. Hepatology. 2016 Jun;63(6):1888-99.

  • Swiss National Science Foundation (SNF)
  • Swiss Cancer League
  • Krebsliga beider Basel
  • Forschungsfond Universität Basel