Forschung
Der Hauptakzent der Forschung liegt heute in der klinischen Erprobung der künstlichen Bandscheiben an der Hals- und Lendenwirbelsäule, ferner in der Behandlung der Spinalstenose sowie der Osteoporosefraktur.
Die Spinale Chirurgie hat am Universitätsspital Basel eine lange Tradition. An der Orthopädischen Klinik wurden im Laufe der Jahren mehrere Implantatsysteme entwickelt.
Prof. Stefan Schären ist seit dem 1.7.2014 Chefarzt der Spinalen Chirurgie.
Prof. Bernard Jeanneret, Chefarzt der Abteilung für Wirbelsäulenchirurgie von 1996 bis 2013, entwickelte zusammen mit der AO 1993 den CerviFix, ein Implantatsystem zur dorsalen Stabilisation von Instabilitäten an der Halswirbelsäule.
Prof. Walter Dick, Vorsteher der Orthopädischen Klinik bis 2008, entwickelte ebenfalls in Zusammenarbeit mit der AO 1982 der Fixateur interne zur dorsalen kurzstreckigen Stabilisation von Wirbelfrakturen der thoracolumbalen Wirbelsäule.
Prof. Erwin Morscher, Vorsteher der orthopädischen Klinik bis 1995, entwickelte in den Achtziger Jahren zusammen mit der AO (Arbeitsgemeinschaft für Osteosynthese) die ventrale Verriegelungsplatte an der Halswirbelsäule sowie die Haken für die Stabilisation von Spondylolysen an der Lendenwirbelsäule.
Das Basler Labor für funktionelle Biomechanik (BFBL) wurde 2015 gegründet und bündelt die Expertise in der humanbiomechanischen Forschung sowie in der orthopädischen Chirurgie und Sportmedizin und wird von Prof. Dr. Annegret Mündermann und Dr. Corina Nüesch geleitet.
Das BFBL ist Teil der Orthopädie und Traumatologie (Vorsitzender Prof. Dr. Daniel Rikli) und der Spinalen Chirurgie (Vorsitzender Prof. Dr. Stefan Schären) am Universitätsspital Basel, Schweiz. Das BFBL befindet sich im Bettenhaus 3 des Universitätsspitals Basel.
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zu unseren verschiedenen Forschungsprojekten
innerhalb der Abteilung klinischen Forschung.
Unsere Publikationen
Alle unsere Publikationen finden Sie hier.
Ausgewählte Publikationen
2023
Ausgewählte Publikationen 2023:
Is Age a Risk Factor for Early Postoperative Cage Subsidence After Transforaminal Lumbar Interbody Fusion? A Retrospective Study in 170 Patients.
Zhang Y, Nüesch C, Mündermann A, Halbeisen F, Schären S, Netzer C.
Global Spine J. 2023 Nov 21:21925682231217692. doi: 10.1177/21925682231217692. Online ahead of print.
PMID: 38124312
https://pubmed.ncbi.nlm.nih.gov/38124312/
The role of muscle degeneration and spinal balance in the pathophysiology of lumbar spinal stenosis: Study protocol of a translational approach combining in vivo biomechanical experiments with clinical and radiological parameters.
Koch D, Nüesch C, Ignasiak D, Aghlmandi S, Caimi A, Perrot G, Prüfer F, Harder D, Santini F, Schären S, Ferguson S, Mündermann A, Netzer C.
PLoS One. 2023 Oct 27;18(10):e0293435. doi: 10.1371/journal.pone.0293435. eCollection 2023.
PMID: 37889898
https://pubmed.ncbi.nlm.nih.gov/37889898/
Perception of frailty in spinal metastatic disease: international survey of the AO Spine community.
MacLean MA, Georgiopoulos M, Charest-Morin R, Goodwin CR, Laufer I, Dea N, Shin JH, Gokaslan ZL, Rhines LD, O'Toole JE, Sciubba DM, Fehlings MG, Stephens BF, Bettegowda C, Myrehaug S, Disch AC, Netzer C, Kumar N, Sahgal A, Germscheid NM, Weber MH; AO Spine Knowledge Forum Tumor.
J Neurosurg Spine. 2023 Mar 3:1-11. doi: 10.3171/2023.1.SPINE221433. Online ahead of print.
PMID: 36883617
https://pubmed.ncbi.nlm.nih.gov/36883617/
Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc.
Kasamkattil J, Gryadunova A, Schmid R, Gay-Dujak MHP, Dasen B, Hilpert M, Pelttari K, Martin I, Schären S, Barbero A, Krupkova O, Mehrkens A.
Front Bioeng Biotechnol. 2023 Feb 14;11:1119009. doi: 10.3389/fbioe.2023.1119009. eCollection 2023.
PMID: 36865027
https://pubmed.ncbi.nlm.nih.gov/36865027/
Kinematics and paraspinal muscle activation patterns during walking differ between patients with lumbar spinal stenosis and controls.
Nüesch C, Mandelli F, Przybilla P, Schären S, Mündermann A, Netzer C.
Gait Posture. 2023 Jan;99:44-50. doi: 10.1016/j.gaitpost.2022.10.017. Epub 2022 Oct 26.
PMID: 36327537
2022
Ausgewählte Publikationen 2022:
Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review.
MacLean MA, Touchette CJ, Georgiopoulos M, Brunette-Clément T, Abduljabbar FH, Ames CP, Bettegowda C, Charest-Morin R, Dea N, Fehlings MG, Gokaslan ZL, Goodwin CR, Laufer I, Netzer C, Rhines LD, Sahgal A, Shin JH, Sciubba DM, Stephens BF, Fourney DR, Weber MH; AO Spine Knowledge Forum Tumor.
Lancet Oncol. 2022 Jul;23(7):e321-e333. doi: 10.1016/S1470-2045(22)00126-7.
PMID: 35772464
https://pubmed.ncbi.nlm.nih.gov/35772464/
Posterior stabilization with polyetheretherketone (PEEK) rods and transforaminal lumbar interbody fusion (TLIF) with titanium rods for single-level lumbar spine degenerative disease in patients above 70 years of age.
Kamenova M, Li E, Soleman J, Fiebig O, Mehrkens A, Schaeren S.
Arch Orthop Trauma Surg. 2022 May 5. doi: 10.1007/s00402-022-04448-8. Online ahead of print.
PMID: 35511354
Link: https://pubmed.ncbi.nlm.nih.gov/35511354/
Localization of Nerve Growth Factor Expression to Structurally Damaged Cartilaginous Tissues in Human Lumbar Facet Joint Osteoarthritis.
Seidel MF, Netzer C, Chobaz V, Hügle T, Geurts J.
Front Immunol. 2022 Mar 1;13:783076. doi: 10.3389/fimmu.2022.783076. eCollection 2022.
PMID: 35300334
https://pubmed.ncbi.nlm.nih.gov/35300334/
Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc.
Kasamkattil J, Gryadunova A, Martin I, Barbero A, Schären S, Krupkova O, Mehrkens A.
Int J Mol Sci. 2022 Feb 25;23(5):2530. doi: 10.3390/ijms23052530.
PMID: 35269672
https://pubmed.ncbi.nlm.nih.gov/35269672/
Radiographic study of peak velocity of pelvic incidence in adolescent idiopathic scoliosis.
Zhang Y, Shu S, Gu Q, Mandelli F, Zhang T, Jing W, Qiu Y, Zhu Z, Bao H.
Quant Imaging Med Surg. 2022 Feb;12(2):1130-1138. doi: 10.21037/qims-21-391.
PMID: 35111610
https://pubmed.ncbi.nlm.nih.gov/35111610/
2021
Association between fat infiltration of paraspinal muscle, sagittal pelvic alignment and stenosis grade in patients with degenerative lumbar spinal stenosis
Zhang Y , Mandelli F, Mündermann A, Nüesch C, Kovacs B, Schären S, Netzer C.North Am Spine Soc J 2021, 5:100054. Link
Cross-cultural adaptation of the spine oncology-specific SOSGOQ2 questionnaire to German language and the assessment of its validity and reliability in the clinical setting"
Datzmann T, Kisel W, Kramer J, Dreimann M, Müller-Broich J D, Netzer C, Schaser KD, Schmitt J, Disch A C, Tumor Study Group, Spine Section of the German Society of Orthopaedic and Trauma Surgeons (DGOU)BMC Cancer 06.07.2021 DOI: 10.1186/s12885-021-08578-x Link
Assessing fatty infiltration of paraspinal muscles in patients with lumbar spinal stenosis: Goutallier classification and quantitative MRI measurements
Mandelli F, Nüesch C, Zhang Y, Halbeisen F, Schären S, Mündermann A, Netzer C.Frontiers in Neurology 2021 September Pubmed Link
Nose to Spine: spheroids generated by human nasal chondrocytes for scaffold-free nucleus pulposus augmentation.
Gryadunova A, Kasamkattil J, Gay MHP, Dasen B, Pelttari K, Mironov V, Martin I, Schären S, Barbero A, Krupkova O, Mehrkens A.Acta Biomater. 2021 Jul 31:S1742-7061(21)00502-X. doi: 10.1016/j.actbio.2021.07.064. Pubmed Link
Intradural extraarachnoid sutureless technique combined with laminoplasty for indirect repair of ventral dural defects in spontaneous intracranial hypotension: technical note and case series
Kamenova M, Schaeren S, Wasner M-GActa Neurochir (Wien). 2021 Sep;163(9):2551-2556. doi: 10.1007/s00701-021-04868-2. Epub 2021 May 8. Pubmed Link
2020
Severity of degenerative lumbar spinal stenosis affects pelvic rigidity during walking
Bumann H, Nüesch C, Loske S, Byrnes K, Kovacs B, Janssen R, Schären S, Mündermann A, Netzer CSpine J 2020 January, 20:112−120. Pubmed Link
Novel patient-specific 3D-virtual reality visualisation software (SpectoVR) for the planning of spine surgery: a case series of eight patients
Croci DM, Guzman R, Netzer C, Mariani L, Schaeren S, Cattin PC; Jost GBMJ Innovations 2020 6 (4) Link
Parvimonas micra as a rare cause of spondylodiscitis - case series from a single centre
Durovic A, Eberhard N, Schären S, Widmer AF.Swiss Med Wkly. 2020 Jun 16;150:w20272. doi: 10.4414/smw.2020.20272. PMID: 32579699. Pubmed Link
2019
Nose to back: compatibility of nasal chondrocytes with environmental conditions mimicking a degenerated intervertebral disc
Gay MH, Mehrkens A, Rittmann M, Haug M, Barbero A, Martin I, Schaeren S.Eur Cell Mater. 2019 Mar 22;37:214-232. Pubmed Link
Inertial measurement unit-assisted implantation of pedicle screws in combination with an intraoperative 3-dimensional/2-dimensional visualization of the spine
Jost GF, Walti J, Mariani L, Schaeren S, Cattin P.Oper Neurosurg (Hagerstown). 2019 Mar 1;16(3):326-334. Pubmed Link
Direct oral anticoagulants in patients undergoing spine surgery
Croci DM, Dalolio M, Guzman R, Mariani L, Schaeren S, Kamenova M, Soleman J.World Neurosurg. 2019 Feb 15. pii: S1878-8750(19)30349-3. Pubmed Link
Outcome of spinal surgery in patients older than age 90 years
Rychen J, Stricker S, Mariani L, Schaeren S, Jost GF.World Neurosurg. 2019 Mar;123:e457-e464. Pubmed Link
Direct Oral Anticoagulants in Patients Undergoing Spine Surgery.
Croci DM, Dalolio M, Guzman R, Mariani L, Schaeren S, Kamenova M and Soleman J.World Neurosurg. 2019 May;125:e1034-e1041. doi: 10.1016/j.wneu.2019.01.236. Epub 2019 Feb 15. PMID: 30776515 Pubmed Link
2018
Decompression surgery improves gait quality in patients with symptomatic lumbar spinal stenosis
Loske S, Nüesch C, Byrnes KS, Fiebig O, Schären S, Mündermann A, Netzer C.Spine J. 2018 Dec;18(12):2195-2204. Pubmed Link
Novel ex vivo human osteochondral explant model of knee and spine osteoarthritis enables assessment of inflammatory and drug treatment responses
Geurts J, Jurić D, Müller M, Schären S, Netzer C.Int J Mol Sci. 2018 Apr 28;19(5). pii: E1314. Pubmed Link
Comparative analysis of bone structural parameters reveals subchondral cortical plate resorption and increased trabecular bone remodeling in human facet joint osteoarthritis
Netzer C, Distel P, Wolfram U, Deyhle H, Jost GF, Schären S, Geurts J.Int J Mol Sci. 2018 Mar 14;19(3). pii: E845. Pubmed Link
Inertial sensor based gait and attractor analysis as clinical measurement tool: functionality/sensitivity in patients with symptomatic lumbar spinal stenosis and healthy subjects
Byrnes K, Nüesch C, Loske S, Schären S, Netzer C, Mündermann A.Frontiers Physiology 2018 August 9:1095. doi: 10.3389/fphys.2018.01095. Pubmed Link
Minimum ten-year follow-up of spinal stenosis with degenerative spondylolisthesis treated with decompression and dynamic stabilization.
Veresciagina K, Mehrkens A, Schären S, Jeanneret B.J Spine Surg. 2018 Mar;4(1):93-101. doi: 10.21037/jss.2018.03.20. Pubmed Link
2017
GEORG-SCHMORL-PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2016: Comparison of in vitro osteogenic potential of iliac crest and degenerative facet joint bone autografts for intervertebral fusion in lumbar spinal stenosis
Geurts J, Ramp D, Schären S, Netzer C.Eur Spine J. 2017 May;26(5):1408-1415. Pubmed Link
Inertial measurement unit-assisted implantation of thoracic, lumbar, and sacral pedicle screws improves precision of a freehand technique
Jost GF, Walti J, Mariani L, Schaeren S, Cattin P.World Neurosurg. 2017 Jul;103:11-18. Pubmed Link
Notochordal cell-derived conditioned medium protects human nucleus pulposus cells from stress-induced apoptosis
Mehrkens A, Matta A, Karim MZ, Kim S, Fehlings MG, Schaeren S, Mark Erwin W.Spine J. 2017 Apr;17(4):579-588. Pubmed Link
2016
Characterization of subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal stenosis
Netzer C, Urech K, Hügle T, Benz RM, Geurts J, Schären S.J Orthop Res. 2016 Aug;34(8):1475-80. Pubmed Link
Platelet concentrates in spine fusion: meta-analysis of union rates and complications in controlled trials
Vavken J, Vavken P, Mameghani A, Camathias C, Schaeren S.Eur Spine J. 2016 May;25(5):1474-1483. Pubmed Link
Complications and cancer rates in spine fusion with recombinant human bone morphogenetic protein-2 (rhBMP-2)
Vavken J, Mameghani A, Vavken P, Schaeren S.Eur Spine J. 2016 Dec;25(12):3979-3989. Pubmed Link
A novel approach to navigated implantation of S-2 alar iliac screws using inertial measurement units
Jost GF, Walti J, Mariani L, Cattin P.J Neurosurg Spine. 2016 Mar;24(3):447-53. Pubmed Link
Management of Incidental Dural Tear During Lumbar Spine Surgery. To Suture or Not to Suture?
Kamenova M, Leu S, Mariani L, Schaeren S, Soleman J.World Neurosurg. 2016 Mar;87:455-62. doi: 10.1016/j.wneu.2015.11.045. Epub 2015 Dec 14. Pubmed Link
Preoperative and Postoperative Factors and Laboratory Values Predicting Outcome in Patients Undergoing Lumbar Fusion Surgery.
Leu S, Kamenova M, Mehrkens A, Mariani L, Schären S, Soleman J.World Neurosurg. 2016 Aug;92:323-338. doi: 10.1016/j.wneu.2016.05.011. Epub 2016 May 13. PMID: 27184898 Pubmed Link
